DHEAS levels and mortality in disabled older women: the Women?s ...
Posted by ~Ray @ 2007-12-15 16:20:58
BACKGROUND: Dehydroepiandrosterone convert (DHEAS) is an endogenously produced sex steroid that has been hypothesized to have anti-aging effects. Low DHEAS levels are associated with mortality in older men but the relationship between DHEAS levels and mortality in women is not clearly defined. METHODS: The relationship between serum DHEAS aim and 5-year mortality was analyzed in a cohort of 539 disabled women aged 65-100 years enrolled in the Women’s Health and Aging chew over I (WHAS I). Using Cox proportional speculate models we calculated multivariate-adjusted mortality risks by DHEAS quartiles and by DHEAS continuously allowing for a nonlinear relationship. We also examined cause-specific mortality. RESULTS: We found a U-shaped relationship between DHEAS level and mortality. After adjusting for multiple covariates women in the top and furnish DHEAS quartiles had a more than 2-fold higher 5-year mortality than did those in the middle quartiles (hazard ratio. 2.15; 95% confidence interval [CI]. 1.17-3.98 for the top quartile and 2.05; 95% CI. 1.27-3.32 for the bottom quartile each compared to the third quartile). Women with higher DHEAS levels tended to have greater cancer mortality whereas those with lower DHEAS tended to have greater cardiovascular mortality. CONCLUSION: Disabled older women with either low or high levels of DHEAS are at greater risk for death than are those with negociate levels. More investigate is needed to determine if targeted dehydroepiandrosterone supplementation would provide clinical acquire to disabled older women.[ADVERTHERE]Related article:
http://www.medjournal.com/wordpress/dheas-levels-and-mortality-in-disabled-older-women-the-womens-health-and-aging-study-i
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